Related Experiment Video

Updated: Aug 25, 2026

Procedure for Human Saphenous Veins Ex Vivo Perfusion and External Reinforcement
09:50

Procedure for Human Saphenous Veins Ex Vivo Perfusion and External Reinforcement

Published on: October 1, 2014

[Aging of veins and venules]

J F Merlen, J M Coget

    Phlebologie
    |October 1, 1986
    PubMed

    Insights

    Vascular aging involves interstitial and trunk wall changes, not just blood vessels. This process, similar to plastic aging, leads to stasis and compensatory reactions in elderly patients.

    Area of Science:

    • Gerontology
    • Vascular Biology
    • Connective Tissue Research

    Background:

    • Distinguishes between natural and excessive aging processes.
    • Highlights the interstitial and conjunctival aspects of vascular aging, beyond just the vascular system.
    • Describes clinical and anatomopathological features of venous aging, including phlebosclerosis and proteoglycan deposits.

    Purpose of the Study:

    • To elucidate the mechanisms of vascular aging.
    • To establish an analogy between vascular aging and "plastic" aging.

    Main Methods:

    • Clinical observation and anatomopathological analysis of venous aging.
    • Conceptual framework comparing vascular and plastic aging processes.

    Main Results:

    • Venous aging involves phlebosclerosis and non-homogenous proteoglycan deposits.
    • Elderly patients experience stasis, leading to neogenesis and compensatory membrane thickening.
    • Identifies a control reaction rather than a lesion-induced process in membrane thickening.

    Conclusions:

    • Vascular aging is fundamentally an interstitial and trunk wall issue.
    • Stasis is a key factor in the pathophysiology of aging vasculature.
    • Proposes a unifying principle by drawing an analogy between vascular and plastic aging through polymerization.

    More Related Videos

    A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure07:02

    A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure

    Published on: May 15, 2020

    Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane08:05

    Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

    Published on: December 9, 2022

    Related Concept Videos

    Venules01:08

    Venules

    Venules are an integral part of the microscopic circulatory system that bridges the gap between capillaries and veins.
    Venules are much smaller in diameter compared to their larger counterparts, the veins. They are generally 8 to 100 micrometers in diameter, significantly smaller than the size of veins. The walls of venules are thin, consisting of the endothelium, a thin layer of connective tissue, and occasionally a few smooth muscle cells. This structural simplicity is a stark contrast...
    Veins01:17

    Veins

    Veins are an integral part of our circulatory system, serving as the blood vessels that transport blood from all body regions to the heart. They are a network of hollow tubes that carry blood low in oxygen from the body's cells back to the heart for reoxygenation. Veins are crucial for maintaining the body's overall fluid balance and the continuous circulation of blood.
    Structure of Veins:
    The structure of veins is specifically designed to assist in the low-pressure transportation of blood...
    Veins as Blood Reservoirs01:10

    Veins as Blood Reservoirs

    Veins, while chiefly responsible for circulating blood back to the heart, also function as storage vessels for blood. They house approximately 64 percent of the body's total blood volume, a feat made possible by their high capacitance—the inherent ability to expand and accommodate large volumes of blood, even under low pressure. The large diameter and thin walls of veins augment their distensibility, significantly more so than arteries, due to their classification as capacitance vessels. When...
    Varicose Veins I: Introduction01:26

    Varicose Veins I: Introduction

    Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...
    Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

    Varicose Veins II: Diagnostic Studies and Interprofessional Care

    Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
    Venous Thrombosis I: Introduction01:30

    Venous Thrombosis I: Introduction

    Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...