Related Experiment Video

Updated: Sep 21, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

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Nuclear Receptor Coregulators in Hormone-Dependent Cancers

Hedieh Jafari1,2, Shahid Hussain2, Moray J Campbell2

  • 1Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA.

Cancers
|May 28, 2022
PubMed

Insights

Nuclear receptors (NRs) and their coregulators regulate cellular functions. Understanding their interactions is key to developing new treatments for hormone-dependent cancers like breast and prostate cancer.

Area of Science:

  • Molecular biology
  • Cancer research
  • Endocrinology

Background:

  • Nuclear receptors (NRs) form a signaling network regulating cellular homeostasis.
  • NRs interact with coregulators, proteins essential for modulating gene expression.
  • Dysregulated coregulator expression is implicated in hormone-dependent cancers.

Purpose of the Study:

  • To review recent studies on NR-coregulator interactions in hormone-dependent cancers.
  • To summarize techniques and bioinformatics methods for identifying aberrant interactions.
  • To highlight the role of these interactions as cancer drivers.

Main Methods:

  • Literature review of recent studies.
  • Analysis of techniques for identifying NR-coregulator interactions.
  • Evaluation of bioinformatics approaches.

Main Results:

  • Coregulators critically control NR activity and gene transcription.
  • Altered NR-coregulator interactions contribute to cancer development.
  • Recent advancements offer new ways to study these complex interactions.

Conclusions:

  • Understanding NR-coregulator mechanisms is vital for cancer research.
  • Identifying distorted interactions can lead to improved diagnostics and therapeutics.
  • This review consolidates current knowledge to guide future research.
Keywords:
breast cancerchromatincoactivatorscorepressorsepigenetichormone dependent cancersnuclear receptorsprostate cancertherapy resistancetranscriptome

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