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SARS-CoV-2 Antigen Testing Intervals: Twice or Thrice a Week?

Chin Shern Lau1, Tar-Choon Aw1,2,3

  • 1Department of Laboratory Medicine, Changi General Hospital, Singapore 529889, Singapore.

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|May 28, 2022
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Summary

Routine antigen testing for SARS-CoV-2 (the virus that causes COVID-19) twice or thrice weekly showed no difference in detecting infections. This study evaluated optimal COVID-19 screening frequency for healthcare workers.

Keywords:
SARS-CoV-2antigenfrequency

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Area of Science:

  • Infectious Diseases
  • Public Health Surveillance
  • Diagnostic Testing

Background:

  • Antigen testing for SARS-CoV-2 is a key screening tool during the COVID-19 pandemic.
  • Recommended testing frequencies vary, with the CDC suggesting 1-3 times weekly and some experts advocating for 2-3 times weekly.
  • The optimal frequency for antigen testing remains unclear.

Purpose of the Study:

  • To compare the effectiveness of twice-weekly versus thrice-weekly SARS-CoV-2 antigen testing in a healthcare setting.
  • To evaluate the utility of frequent antigen testing as a screening tool for COVID-19 surveillance.

Main Methods:

  • A laboratory staff of 161 individuals participated in routine COVID-19 surveillance.
  • Participants underwent either twice-weekly or thrice-weekly SARS-CoV-2 antigen testing during different periods from August 2021 onwards.
  • No COVID-19 cases were detected during the surveillance periods under either testing regimen.

Main Results:

  • No SARS-CoV-2 infections were identified with either twice-weekly or thrice-weekly antigen testing protocols.
  • The study found no significant difference in screening effectiveness between testing twice or thrice per week.
  • Frequent antigen testing did not detect any COVID-19 cases among the healthcare worker staff.

Conclusions:

  • Performing SARS-CoV-2 antigen tests twice or thrice weekly demonstrates no inferiority to each other for COVID-19 screening.
  • Frequent antigen testing can serve as a valuable surrogate for RT-PCR testing in surveillance settings.
  • The study suggests that current frequent testing protocols are effective in detecting COVID-19 in this specific healthcare setting.