Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transcellular Transport of Solutes01:23

Transcellular Transport of Solutes

3.9K
Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
3.9K
Reabsorption and Secretion in the DCT and Collecting Duct01:26

Reabsorption and Secretion in the DCT and Collecting Duct

1.6K
The early phase of the DCT manages the reabsorption of approximately 10-15% of filtered water, 5–10% of filtered sodium, and 5–10% of filtered chloride. This process is facilitated by Na+–Cl− symporters in apical membranes and sodium-potassium pumps, as well as Cl− leakage channels in basolateral membranes. The early DCT also stands out as a site where parathyroid hormone (PTH) stimulates calcium reabsorption, depending on the body's requirements.
The distal...
1.6K
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

307
Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
307
Reabsorption and Secretion in the PCT01:28

Reabsorption and Secretion in the PCT

1.8K
The Proximal Convoluted Tubule, or PCT, plays a pivotal role in the body's filtration system. They are primarily responsible for reabsorbing solutes and water from the filtered fluid produced by the glomeruli. Most of the filtered water, ions, and organic solutes such as glucose and amino acids are reabsorbed by the PCT.
Transport mechanisms involving sodium ions (Na+) contribute significantly to solute reabsorption. These mechanisms include symport and antiport processes.
A key example is the...
1.8K
Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion01:22

Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion

116
The kidneys maintain homeostasis through filtration, reabsorption, and secretion. Tubular reabsorption and secretion are crucial in forming urine and regulating electrolytes, water balance, and waste elimination.Tubular Reabsorption and Secretion ProcessesTubular reabsorption is the process that reclaims essential substances such as electrolytes, glucose, amino acids, and water from the glomerular filtrate back into the bloodstream. This is achieved through passive and active transport...
116
Tubular Reabsorption and Secretion01:28

Tubular Reabsorption and Secretion

3.4K
Tubular secretion and reabsorption are two critical processes in the nephron tubule of the kidneys. When the fluid filtered from the glomerulus enters the proximal convoluted tubule, it is referred to as filtrate, and its composition changes due to tubular reabsorption and secretion.
Tubular reabsorption is a selective process that starts when the filtrate enters the proximal tubules. It involves substances traveling through the transcellular route (through the tubule cell and peritubular...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simple-to-Fabricate and Water-Stable Instrument Markers for Preclinical Magnetic Particle Imaging and Magnetic Resonance Imaging.

Medical devices (Auckland, N.Z.)·2026
Same author

Uptake characteristics of MRI and CT contrast agents in 3D printing materials for vascular phantoms.

3D printing in medicine·2025
Same author

Development and deployment of a functional 3D-bioprinted blood vessel.

Scientific reports·2025
Same author

Application of a 3D bioprinter: jet technology for 'biopatch' development using cells on hydrogel supports.

BioTechniques·2023
Same author

Three-Dimensional Bioprinting Applications for Bone Tissue Engineering.

Cells·2023
Same author

3D Bioprinting Using Hydrogels: Cell Inks and Tissue Engineering Applications.

Pharmaceutics·2022
Same journal

Correction: Verde et al. Molecular Mechanisms of Protein Aggregation in ALS-FTD: Focus on TDP-43 and Cellular Protective Responses. <i>Cells</i> 2025, <i>14</i>, 680.

Cells·2026
Same journal

Inflammation in Cardiomyopathies: Cellular Mechanisms Across Cardiac Phenotype.

Cells·2026
Same journal

IL-4/IL-13-Driven Dysregulation of Epidermal Lipid Metabolism in Atopic Dermatitis: An Immunometabolic Link Between Type 2 Inflammation and Barrier Dysfunction.

Cells·2026
Same journal

Activity of DNA- and RNA-Guided Prokaryotic Argonautes in Human Mitochondria.

Cells·2026
Same journal

Placental Pathophysiology in Maternal Psychoactive Substance Use: Biological, Clinical, and Forensic Perspectives.

Cells·2026
Same journal

PACAP and Maxadilan (PAC1 Agonist) Influence Plaque Progression, Migratory Ability, and Mitochondrial Morphology and Dynamics in Vascular Smooth Muscle Cells.

Cells·2026
See all related articles

Related Experiment Video

Updated: Sep 21, 2025

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

588

Colonic Fluid and Electrolyte Transport 2022: An Update.

Abel B Negussie1, Annika C Dell2, Bruce A Davis3

  • 1Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06510, USA.

Cells
|May 28, 2022
PubMed
Summary
This summary is machine-generated.

This review updates the model of colonic ion transport, focusing on key proteins like CFTR and ENaC. Understanding these mechanisms is crucial for maintaining gut health and treating diseases like IBS and cystic fibrosis.

Keywords:
CFTRENaCH,KATPaseIBSNHENKCCcolon physiologycolonic ion transport

More Related Videos

Two-dimensional Porcine Intestinal Organoids Reflecting the Physiological Properties of Native Gut
09:13

Two-dimensional Porcine Intestinal Organoids Reflecting the Physiological Properties of Native Gut

Published on: January 31, 2025

623
Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

27.3K

Related Experiment Videos

Last Updated: Sep 21, 2025

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

588
Two-dimensional Porcine Intestinal Organoids Reflecting the Physiological Properties of Native Gut
09:13

Two-dimensional Porcine Intestinal Organoids Reflecting the Physiological Properties of Native Gut

Published on: January 31, 2025

623
Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

27.3K

Area of Science:

  • Gastroenterology
  • Cell Biology
  • Physiology

Background:

  • Colonic epithelial cells maintain fluid and ion balance through complex transport mechanisms.
  • Dysregulation of these processes contributes to various gastrointestinal diseases.

Purpose of the Study:

  • To provide an updated model of colonic electrolyte transport.
  • To highlight the roles of key ion transporters and their regulation.

Main Methods:

  • Review of existing literature on colonic ion transport.
  • Synthesis of current understanding of transporter activity, regulation, and interactions.

Main Results:

  • Detailed examination of transporters including CFTR, ENaC, NKCCs, NHEs, and H,KATPase.
  • Elucidation of their roles in pH modulation, osmotic gradients, and cell death.
  • Exploration of regulatory pathways and inter-transporter relationships.

Conclusions:

  • A robust model of colonic ion homeostasis is essential for understanding normal function and disease.
  • Disruptions in ion transport are implicated in diarrhea, constipation, and pathologies such as cystic fibrosis and IBD.