USP10 as a Potential Therapeutic Target in Human Cancers

Area of Science:

• Biochemistry
• Molecular Biology
• Oncology

Background:

• Deubiquitination is a critical post-translational modification regulating protein homeostasis.
• Deubiquitinating enzymes (DUBs) are key regulators, with USP10 being a prominent member of the USP family.
• USP10's dual role in human cancers, acting as both an oncogene and tumor suppressor, is increasingly recognized but mechanistically complex.

Purpose of the Study:

• To review the downstream substrates and upstream regulators of USP10.
• To elucidate the dual role of USP10 as an oncogene and tumor suppressor in various human cancers.
• To summarize existing pharmacological inhibitors of USP10.

Main Methods:

• Literature review of studies on USP10 function in cancer.
• Analysis of USP10's substrates and regulators.
• Compilation of information on USP10 inhibitors, including small molecules and traditional Chinese medicines.

Main Results:

• USP10 exhibits context-dependent functions in tumorigenesis, acting as either an oncogene or tumor suppressor.
• Specific upstream regulators and downstream substrates influence USP10's oncogenic or tumor-suppressive activities.
• Various pharmacological inhibitors targeting USP10 have been identified, including spautin-1.

Conclusions:

• USP10's multifaceted role in cancer necessitates a context-specific therapeutic approach.
• Targeting USP10, particularly its oncogenic functions, presents a promising strategy for cancer treatment.
• Development of specific and efficient USP10 inhibitors tailored to different cancer types holds therapeutic potential.