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Histone Modifications and Non-Coding RNAs: Mutual Epigenetic Regulation and Role in Pathogenesis
Irina V Bure1, Marina V Nemtsova1,2, Ekaterina B Kuznetsova1
1Laboratory of Medical Genetics, I. M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
International Journal of Molecular Sciences
|May 28, 2022
Summary
Epigenetic regulators, including histone modifications and non-coding RNAs (ncRNAs), form complex networks crucial for understanding disease development. These dynamic epigenetic changes offer potential as biomarkers and therapeutic targets.
Area of Science:
- Molecular Biology
- Genetics
- Epigenetics
Background:
- Epigenetic regulators form intricate networks of pathways and feedback loops.
- Aberrations in epigenetic processes are linked to the development and progression of various diseases.
- Epigenetic modifications are observable in preclinical disease stages, suggesting biomarker potential.
Purpose of the Study:
- To review the mutual regulation between histone modifications and non-coding RNAs (ncRNAs).
- To explore the role of these epigenetic factors in cellular processes.
- To discuss the potential clinical applications of targeting epigenetic modifications.
Main Methods:
- Literature review focusing on histone modifications and ncRNAs.
- Analysis of regulatory interactions and feedback loops.
- Examination of roles in cellular functions and disease pathogenesis.
Main Results:
- Epigenetic regulators, specifically histone modifications and ncRNAs, are interconnected.
- These interactions play significant roles in cellular processes and disease progression.
- Dynamic and reversible epigenetic modifications present therapeutic opportunities.
Conclusions:
- The network of epigenetic regulators is vital for understanding disease mechanisms.
- Epigenetic aberrations can serve as early disease biomarkers.
- Targeting histone modifications and ncRNAs offers a promising avenue for novel therapeutic strategies.
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