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Hypertension in Patients with Insulin Resistance: Etiopathogenesis and Management in Children

Veronica Maria Tagi1, Francesca Mainieri1, Francesco Chiarelli1

  • 1Department of Pediatrics, University of Chieti, Via dei Vestini 5, 66100 Chieti, Italy.

International Journal of Molecular Sciences
|May 28, 2022
PubMed

Insights

Insulin resistance (IR) contributes to hypertension (HS) in diabetes mellitus (DM) patients. This review highlights IR

Area of Science:

  • Endocrinology
  • Cardiology
  • Pediatrics

Background:

  • Insulin resistance (IR) is a significant factor in the development of hypertension (HS) among individuals with diabetes mellitus (DM).
  • Recent literature indicates multiple complex pathways linking IR to HS.
  • Specific management of HS is crucial for pediatric patients with DM.

Purpose of the Study:

  • To elucidate the pathophysiological mechanisms by which IR contributes to HS.
  • To outline the specialized treatment principles for HS in children with DM.

Main Methods:

  • Literature review of recent studies on IR, HS, and DM.
  • Analysis of current European Society of HS and American Academy of Pediatrics guidelines.

Main Results:

  • IR influences HS through various interconnected biological pathways.
  • Current guidelines emphasize tailored HS treatment strategies for diabetic children.

Conclusions:

  • Understanding the IR-HS link is vital for managing hypertension in diabetic children.
  • Adherence to updated guidelines ensures optimal HS treatment for this vulnerable population.

Keywords:
childrendiabetes mellitushypertensioninsulin resistance

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