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Biomarkers of Myocardial Injury and Remodeling in Heart Failure

Barbara Ponikowska1, Gracjan Iwanek2, Agata Zdanowicz2

  • 1Student Scientific Organization, Wroclaw Medical University, 50-556 Wroclaw, Poland.

Journal of Personalized Medicine
|May 28, 2022
PubMed

Insights

This review examines cardiovascular biomarkers for heart failure, including those for myocardial remodeling, fibrosis, myocyte injury, and iron metabolism. These biomarkers offer potential for improved diagnosis, treatment, and prognosis of heart failure.

Area of Science:

  • Cardiology
  • Biomarker Research

Background:

  • Heart failure is a significant public health concern due to its complex pathophysiology and high prevalence.
  • Current diagnostic and prognostic tools for heart failure require enhancement.

Purpose of the Study:

  • To review the clinical applicability and significance of various cardiovascular biomarkers.
  • To explore biomarkers related to myocardial remodeling, fibrosis, myocyte injury, and iron metabolism.

Main Methods:

  • Literature review of existing studies on cardiovascular biomarkers.
  • Analysis of biomarkers including galectin-3, ST2, MMPs, osteopontin, IL-6, syndecan-4, myostatin, P1NP, P3NP, VEGF, NOS, ADMA, H-FABP, GSTP1, HSP60, ferritin, transferrin saturation, sTfR, and hepcidin.

Main Results:

  • Identified key biomarkers for myocardial remodeling and fibrosis, such as galectin-3 and ST2.
  • Highlighted biomarkers for myocyte injury (e.g., H-FABP) and iron metabolism (e.g., ferritin, hepcidin).
  • Discussed the potential clinical significance and applicability of these diverse biomarkers.

Conclusions:

  • Cardiovascular biomarkers show promise for advancing heart failure diagnosis, treatment, and prognosis.
  • Further research is warranted to fully integrate these biomarkers into clinical practice.

Keywords:
biomarkersheart failureheart injuryremodeling

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