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Phenolic compounds can induce systemic and central immunomodulation, which result in a neuroprotective effect
J Abraham Domínguez-Avila1, Norma J Salazar-López2,3, Marcelino Montiel-Herrera4
1Cátedras CONACYT-Centro de Investigación en Alimentación y Desarrollo A. C., Hermosillo, Mexico.
Journal of Food Biochemistry
|May 28, 2022
Summary
Phenolic compounds found in fruits and vegetables possess anti-inflammatory properties. Regular consumption of these foods helps regulate the immune response, protecting both systemic and central nervous system health.
Area of Science:
- Nutrition Science
- Immunology
- Neuroscience
Background:
- Inflammation poses risks to overall health, especially the central nervous system.
- Phenolic compounds from fruits and vegetables show promise for anti-inflammatory effects.
Purpose of the Study:
- To review the immunomodulatory effects of phenolic compounds in both peripheral and central nervous systems.
- To explore the potential of dietary phenolics in managing inflammation.
Main Methods:
- Literature review of in vitro and in vivo studies on phenolic compounds.
- Analysis of data on flavonoids and phenolic acids.
- Examination of effects in various inflammation models.
Main Results:
- Phenolic compounds effectively counteract systemic inflammation induced by diet or pathogens.
- Flavonoids and phenolic acids demonstrate significant anti-inflammatory activity in vitro and in vivo.
- Phenolics show therapeutic potential against chronic and acute central nervous system inflammation, including ischemic events.
Conclusions:
- Phenolic compounds possess immunomodulatory potential crucial for maintaining a balanced immune response.
- Prioritizing regular consumption of phenolic-rich foods supports systemic and central nervous system health.
- Specific phenolic compounds warrant further research for developing targeted anti-inflammatory therapies.
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