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Updated: Sep 21, 2025
Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
Published on: April 26, 2019
CURRENT APPROACHES TO DIAGNOSIS AND TREATMENT OF HIRSCHSPRUNG DISEASE IN NEWBORNS AND INFANTS (LITERATURE REVIEW AND
1SHUPYK NATIONAL HEALTHCARE UNIVERSITY OF UKRAINE, KYIV, UKRAINE.
Insights
Hirschsprung disease in newborns requires prompt diagnosis, especially with delayed meconium passage. Early detection and surgical intervention significantly improve outcomes for infants with this congenital condition.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Neonatology
Background:
- Hirschsprung disease is a congenital disorder affecting the large intestine.
- It causes problems with bowel movements and can lead to serious complications in newborns and infants.
Purpose of the Study:
- To review the current understanding of Hirschsprung disease in neonates and infants.
- To synthesize literature data and clinical experience regarding diagnosis and management.
Main Methods:
- Literature review of Hirschsprung disease in newborns and infants.
- Analysis of clinical data and first-hand experience.
Main Results:
- Late meconium passage is a key indicator for suspecting Hirschsprung disease.
- Diagnostic tools include clinical assessment, contrast enema, rectal biopsies, and ACE immunohistochemistry.
- Enterocolitis and intestinal complications like obstruction or perforation are associated with Hirschsprung disease.
Conclusions:
- Suspect Hirschsprung disease in newborns with delayed meconium passage.
- Comprehensive diagnostic approach is crucial for timely identification.
- Early diagnosis and one-stage surgical correction enhance treatment success in infants.
Objective:
The aim: To analyze the current state of the issue of Hirschsprung disease in newborns and infants on the basis of literature data and first-hand experience.
Conclusion:
Conclusions: 1. Hirschsprung disease should be suspected in all newborns with late meconium passage. 2. The main methods of diagnosing Hirschsprung disease in newborns and infants are the assessment of anamnestic data, clinical manifestations and features of the clinical course of the pathology, contrast enema, morphological examination of rectal biopsies and immunohistochemistry for ACE. 3. The presence of enterocolitis in newborns and infants should raise suspicion of Hirschsprung disease. 4. Low intestinal obstruction, perforation of the cecum, ascending or terminal small intestine, and peritonitis in the first days of a child's life may be complications of Hirschsprung disease. 5. In newborns and infants, early diagnosis of Hirschsprung disease and timely surgical correction by one-stage surgery help improve treatment outcomes.
