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Bioactives in the Food Supply: Effects on CVD Health
Sisi Cao1, Connie M Weaver2,3
1Human Nutrition Program, The Ohio State University, Columbus, OH, USA.
Current Atherosclerosis Reports
|May 28, 2022
Summary
Bioactive compounds show promise in preventing cardiovascular disease beyond basic nutrition. New guidance frameworks are emerging to establish policy for these substances, targeting key health areas.
Area of Science:
- Nutritional Science
- Cardiovascular Health
- Pharmacology
Background:
- Interest in preventing atherosclerosis and cardiovascular disease extends beyond essential nutrients and dietary patterns.
- Bioactive compounds are increasingly recognized for their potential health benefits.
Purpose of the Study:
- To review the potential role of bioactive compounds in preventing atherosclerosis and cardiovascular disease.
- To discuss the recent development of guidance for creating policy related to bioactive substances.
Main Methods:
- Literature review of studies on bioactive compounds and cardiovascular health.
- Analysis of emerging frameworks for developing policy on bioactive substances.
Main Results:
- A framework for developing recommended intakes of dietary bioactive substances has been established.
- The first guideline is anticipated for a bioactive targeting cardiometabolic health.
- Bioactives impact endothelial health, gut microbiome, serum lipids, blood pressure, inflammation, and oxidative stress.
Conclusions:
- The evidence base for bioactive compounds in disease prevention is growing.
- Development of robust biomarkers for exposure and health outcomes will enhance the evidence base.
- Strong evidence is crucial for developing policy and influencing clinical practice regarding bioactives.
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