Related Experiment Video

Updated: Sep 21, 2025

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Effectiveness of Rehabilitation for Cancer Patients with Bone Metastasis

Maki Itokazu¹, Yuji Higashimoto¹, Masami Ueda¹

¹Department of Rehabilitation Medicine, Graduate School of Medical Sciences, Kindai University, Osakasayama City, Japan.

Progress in Rehabilitation Medicine

|May 31, 2022

Abstract

Objectives:

Advances in cancer treatment have led to extended survival, and, as a result, the number of patients with bone metastases is increasing. Activities of daily living (ADL) decrease with bone metastasis and the need for rehabilitation is increasing. This study examined the effects of rehabilitation in patients with bone metastases.

Methods:

We retrospectively reviewed data of cancer patients with bone metastasis who received rehabilitation between 2016 and 2018. Efficacy of rehabilitation was evaluated in 92 patients as the change in the Functional Independence Measure (FIM) score divided by rehabilitation days (FIM change/day) and assessed by different metastatic sites.

Results:

Overall FIM scores significantly improved after rehabilitation. Moreover, FIM change/day improved in patients with pelvic metastases (n=44) more than in patients with other metastatic sites (n=48) (P=0.015). In FIM motor components, improvements in toilet, tub/shower, walk/wheelchair, and stairs were significantly greater in patients with pelvic metastasis than in those with other metastasis sites.

Conclusions:

Rehabilitation improved ADL status to a greater extent in patients with pelvic metastases than in those with other metastasis sites. Patients with pelvic metastases may fear fractures, limiting their ADL, but rehabilitation could eliminate this fear and improve FIM.

Keywords:

Functional Independence Measure (FIM)Katagiri score Mirels score Pelvic metastases Spine Instability Neoplastic Score (SINS)

More Related Videos

Models of Bone Metastasis

Models of Bone Metastasis

Published on: September 4, 2012

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Published on: November 4, 2022

Related Concept Videos

Cancer Survival Analysis

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

Articles linked to this work by shared authors, journal, and citation graph.

Regional differences in 18F-flutemetamol accumulation between amyloid-positive and -negative brains using high-resolution dedicated head PET scanner.

Annals of nuclear medicine·2026

Comprehensive expression analysis of glypicans and syndecans in the mouse embryonic brain.

Gene expression patterns : GEP·2026

Preoperative swallowing muscle mass is associated with 1-year skeletal muscle loss and subsequent survival in lung cancer.

Clinical nutrition (Edinburgh, Scotland)·2026

Comparative clinical utility of preoperative psoas muscle and skeletal muscle index cutoffs for risk stratification after esophagectomy.

Surgery today·2026

Association of Diaphragmatic Crus Thickness Assessed by Computed Tomography with Diaphragmatic Excursion and Exercise Capacity in Patients with Chronic Obstructive Pulmonary Disease.

Lung·2026

Diaphragmatic excursion is associated with longitudinal changes in erector spinae muscle in patients with chronic obstructive pulmonary disease.

Respiratory investigation·2026

See all related articles