Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

163
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
163
Schizophrenia01:17

Schizophrenia

250
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
250
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

226
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
226
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

132
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
132

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Amygdala and hippocampal volumes as neural correlates of resilience and loneliness in older adults.

Neurobiology of aging·2026
Same author

Altered functional hierarchical and sequential organization in individuals with schizophrenia during auditory processing.

NeuroImage·2026
Same author

Two decades of progress in schizophrenia: Evolution, current insights, and future directions.

Spanish journal of psychiatry and mental health·2026
Same author

Decomposing neuroanatomical heterogeneity in depression: insights from an ENIGMA major depressive disorder working group study in 5146 individuals.

Translational psychiatry·2026
Same author

Mapping behavioural mechanisms linking childhood maltreatment, cognition, impulsivity, and suicidality in bipolar disorder: A network approach.

Translational psychiatry·2026
Same author

Visual versus automated collateral scoring on CT angiography for predicting outcome after endovascular therapy for large-vessel occlusion stroke: a prospective multicentre study.

Neuroradiology·2026
Same journal

Vowel acoustic parameters in speech assessment and rehabilitation of minimally verbal and speech-motor-impaired autistic children: a narrative review.

Frontiers in human neuroscience·2026
Same journal

Toward clinical translation of TMS-EEG: an integrative review of multidimensional neurophysiological measures.

Frontiers in human neuroscience·2026
Same journal

The causal efficacy of consciousness: a neuroscientific analysis and explanation.

Frontiers in human neuroscience·2026
Same journal

Temporal-oscillatory entrainment: a multi-timescale framework for rhythmic coordination from neural to social frequencies.

Frontiers in human neuroscience·2026
Same journal

Role of AQP4 in ameliorating heat stress-induced cellular injury in a cell line model through active heat acclimation.

Frontiers in human neuroscience·2026
Same journal

Correction: Cognitive state monitoring for neuroadaptive information visualization.

Frontiers in human neuroscience·2026
See all related articles

Related Experiment Video

Updated: Sep 21, 2025

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.4K

Regularized Functional Connectivity in Schizophrenia.

Raymond Salvador1,2, Paola Fuentes-Claramonte1,2, María Ángeles García-León1,2

  • 1FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.

Frontiers in Human Neuroscience
|May 31, 2022
PubMed
Summary
This summary is machine-generated.

Regularized regression effectively identifies brain functional connectivity abnormalities in schizophrenia patients. This voxel-based method is more sensitive than traditional connectivity analyses for detecting group differences.

Keywords:
functional connectivityglobal brain connectivityresting state fMRIridge regressionschizophrenia

More Related Videos

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.3K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

361

Related Experiment Videos

Last Updated: Sep 21, 2025

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.4K
A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.3K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

361

Area of Science:

  • Neuroscience
  • Brain Imaging
  • Computational Psychiatry

Background:

  • Dimensionality reduction is often used when variables exceed observations.
  • Regularized regression offers an alternative for analyzing high-dimensional data.
  • Previous work quantified brain functional connectivity in healthy controls using regularized regression.

Purpose of the Study:

  • To apply voxel-based regularized regression to detect resting-state functional connectivity abnormalities in schizophrenia.
  • To compare the sensitivity and performance of regularized regression against established connectivity methods.

Main Methods:

  • Ridge regression was implemented with varying regularization parameters.
  • Resting-state functional MRI data from schizophrenia patients were analyzed at the voxel level.
  • Results were compared to weighted global brain connectivity (GBC) and non-redundant connectivity (NRC) methods.

Main Results:

  • Regularized regression identified a greater number of abnormally connected regions compared to GBC and NRC.
  • Connectivity reductions were observed in fronto-medial, somatosensory, and occipital regions in schizophrenia patients.
  • The multivariate nature of regularized regression enhanced sensitivity to group-level connectivity abnormalities.

Conclusions:

  • Voxel-based regularized regression is a simple and sensitive method for quantifying brain functional connectivity.
  • This approach outperforms GBC and NRC in detecting schizophrenia-related connectivity alterations.
  • Regularization provides a valuable alternative to dimensionality reduction in neuroimaging analyses.