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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
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Chromatic visual evoked potentials identify optic nerve dysfunction in patients with Graves' orbitopathy.
Yueqi Yu1,2,3, Bingjie Shi3, Shengnan Cheng3
1Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
International Ophthalmology
|May 31, 2022
Summary
Chromatic visual evoked potentials (cVEP) can detect visual dysfunction in Graves' orbitopathy (GO). Blue-yellow cVEP anomalies may signal early dysthyroid optic neuropathy (DON), while combined R-G cVEP and pattern-reversal VEP (pVEP) offer diagnostic value for DON.
Area of Science:
- Ophthalmology
- Neuroscience
- Electrophysiology
Background:
- Graves' orbitopathy (GO) is an autoimmune condition affecting the eye muscles and tissues.
- Dysthyroid optic neuropathy (DON) is a sight-threatening complication of GO.
- Objective assessment of visual dysfunction in GO and DON is crucial for timely intervention.
Purpose of the Study:
- To objectively analyze visual dysfunction in Graves' orbitopathy (GO) using chromatic visual evoked potentials (cVEP).
- To evaluate the diagnostic efficiency of cVEP for dysthyroid optic neuropathy (DON).
Main Methods:
- A cross-sectional study involving 93 subjects: 21 with DON (Group A), 30 with GO (Group B), and 42 healthy controls (Group C).
- Analysis of pattern-reversal VEP (pVEP), red-green (R-G) cVEP, and blue-yellow (B-Y) cVEP.
- Comparison of electrophysiological parameters across the three groups.
Main Results:
- Blue-yellow cVEP amplitudes were significantly lower in GO patients (Group B) compared to controls (Group C).
- All cVEP parameters and pVEP measures were significantly impaired in DON patients (Group A).
- Combined 60-arcmin cVEP R-G amplitude and 60-arcmin pVEP P100 latency demonstrated superior diagnostic efficiency for DON.
Conclusions:
- Electrophysiological changes, including cVEP anomalies, are associated with Graves' orbitopathy.
- Blue-yellow cVEP abnormalities may indicate preclinical DON in GO patients.
- Combining R-G cVEP and pVEP measures provides a valuable diagnostic index for dysthyroid optic neuropathy.
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