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Fragmented QRS in the relatives of patients with coronary artery disease

Sabri Abuş1, Abdulmecit Afşin1

  • 1Department of Cardiology, Adıyaman University Training and Research Hospital, Adıyaman, Turkey.

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
|May 31, 2022
PubMed

Insights

Fragmented QRS (fQRS), an electrocardiography marker, was elevated in individuals with symptomatic first-degree relatives of coronary artery disease patients. This finding suggests fQRS may indicate increased cardiac risk in those with a family history of CAD.

Area of Science:

  • Cardiology
  • Medical Diagnostics
  • Genetics

Background:

  • Coronary artery disease (CAD) is a leading cause of mortality.
  • Individuals with a family history of CAD may have an increased risk.
  • Fragmented QRS (fQRS) on an electrocardiogram (ECG) is a marker of myocardial damage.

Purpose of the Study:

  • To investigate the prevalence of fQRS in individuals with symptomatic first-degree relatives with CAD.
  • To compare ECG parameters and biochemical markers between individuals with a family history of CAD and healthy controls.

Main Methods:

  • A study included 62 symptomatic individuals with first-degree relatives with CAD and 64 healthy volunteers.
  • Exclusion criteria included known cardiac disease, metabolic disease, or relevant drug use.
  • Electrocardiography (ECG) and biochemical tests (LDL-C, hemoglobin, neutrophil counts) were performed.

Main Results:

  • No significant differences were observed in gender, heart rate, QRS complex, QTc, frontal QRS-T angle, or left ventricle ejection fraction between groups.
  • The QT interval and fQRS count were significantly higher in the study group compared to controls (p < .05).
  • Low-density lipoprotein cholesterol (LDL-C), hemoglobin, and neutrophil counts were also significantly higher in the study group (p < .05).

Conclusions:

  • Fragmented QRS (fQRS) is increased in individuals with symptomatic first-degree relatives of CAD patients.
  • fQRS may serve as a potential indicator of heightened cardiovascular risk in individuals with a family history of CAD.
Abstract

Keywords:
coronary artery diseasefragmented QRSmyocardial scar

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