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Ring replacement recommender: Ring modifications for improving biological activity

Peter Ertl1, Eva Altmann1, Sophie Racine1

  • 1Global Discovery Chemistry, Novartis Institutes for BioMedical Research, CH-4056, Basel, Switzerland.

European Journal of Medicinal Chemistry
|May 31, 2022
PubMed

Keywords:
Bioisosteric replacementBuilding blocksCheminformaticsHeterocyclic ringsHit to lead optimizationLibrary designSubstituents

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