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Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
Published on: August 19, 2015
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A novel use for the biodegradable temporizing matrix
Stephen R Frost1, Avinash Deodhar1, Graham J Offer1
1Department of Plastic Surgery, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, Infirmary Square, Leicester, LE1 5WW UK.
European Journal of Plastic Surgery
|May 31, 2022
Summary
Biodegradable Temporising Matrix (BTM) effectively managed a complex foot and ankle wound from extravasation injury. This skin substitute facilitated healing and pliable skin grafting, preventing contractures.
Area of Science:
- Plastic Surgery
- Wound Healing
- Biomaterials
Background:
- Biodegradable Temporising Matrix (BTM) is a novel skin substitute for reconstructive surgery.
- BTM has shown favorable outcomes in various complex and previously non-graftable wounds.
Purpose of the Study:
- To report the successful use of BTM in managing a specific type of complex wound.
- To highlight BTM as a valuable adjunct in plastic surgery for challenging cases.
Main Methods:
- Case presentation of a patient with a right foot and ankle wound due to extravasation injury.
- Surgical debridement followed by management with BTM to promote granulation and neo-dermis formation.
- Application of a split-thickness skin graft over the BTM-prepared wound bed.
Main Results:
- BTM facilitated the creation of a "neo-dermis", enabling successful split-thickness skin grafting.
- The BTM-treated site resulted in a pliable skin graft and scar, successfully avoiding tendon tethering and joint contracture.
- This represents a novel application of BTM for extravasation injuries of the foot and ankle.
Conclusions:
- Biodegradable Temporising Matrix (BTM) is an effective option for managing complex foot and ankle wounds, particularly those resulting from extravasation injuries.
- BTM promotes favorable wound healing and skin graft take, leading to pliable reconstructions and preventing complications like contractures.
- This case report supports the use of BTM as a valuable adjunct for plastic surgeons managing challenging wounds.

