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Updated: Sep 21, 2025

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

Published on: August 19, 2015

A novel use for the biodegradable temporizing matrix.

Stephen R Frost¹, Avinash Deodhar¹, Graham J Offer¹

¹Department of Plastic Surgery, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, Infirmary Square, Leicester, LE1 5WW UK.

European Journal of Plastic Surgery

|May 31, 2022

Summary

Biodegradable Temporising Matrix (BTM) effectively managed a complex foot and ankle wound from extravasation injury. This skin substitute facilitated healing and pliable skin grafting, preventing contractures.

Keywords:

Biodegradable temporizing matrix Skin graft Tendon tethering

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Last Updated: Sep 21, 2025

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Area of Science:

Plastic Surgery
Wound Healing
Biomaterials

Background:

Biodegradable Temporising Matrix (BTM) is a novel skin substitute for reconstructive surgery.
BTM has shown favorable outcomes in various complex and previously non-graftable wounds.

Purpose of the Study:

To report the successful use of BTM in managing a specific type of complex wound.
To highlight BTM as a valuable adjunct in plastic surgery for challenging cases.

Main Methods:

Case presentation of a patient with a right foot and ankle wound due to extravasation injury.
Surgical debridement followed by management with BTM to promote granulation and neo-dermis formation.
Application of a split-thickness skin graft over the BTM-prepared wound bed.

Main Results:

BTM facilitated the creation of a "neo-dermis", enabling successful split-thickness skin grafting.
The BTM-treated site resulted in a pliable skin graft and scar, successfully avoiding tendon tethering and joint contracture.
This represents a novel application of BTM for extravasation injuries of the foot and ankle.

Conclusions:

Biodegradable Temporising Matrix (BTM) is an effective option for managing complex foot and ankle wounds, particularly those resulting from extravasation injuries.
BTM promotes favorable wound healing and skin graft take, leading to pliable reconstructions and preventing complications like contractures.
This case report supports the use of BTM as a valuable adjunct for plastic surgeons managing challenging wounds.