[Clinical forms and pathophysiology of multiple sclerosis]

"Clinical forms and pathophysiology of multiple sclerosis Multiple sclerosis is a chronic inflammatory disease of the central nervous system. Its triggering mechanisms are still uncertain, but it has been associated with many genetic and environmental factors. Four clinical forms are classically described. In the brain and spinal cord of patients, inflammatory processes cause myelin degradation, axonal de-generation and neuronal loss. Numerous cellular mechanisms related to autoimmunity are involved in the pathophysiology; their activity is associated with the progression to progressive forms of the disease."