[Multiple sclerosis: what therapeutic perspectives ?]

"Multiple sclerosis: what therapeutic perspectives? Three phenomena, which may be interrelated, are at the origin of the accumulation of disability in multiple sclerosis: remyelination defect, persistence of chronic microglial inflammation and neuro¬degeneration. Identifying the molecular and cellular mechanisms and being able to follow them in vivo by advanced imaging repre¬sent a major research challenge for the coming years. Several translational pharmacological avenues have already led to clinical trials targeting remyelination, neuroprotection and control of mi¬croglial activation; however, an optimized methodology with rele¬vant endpoints remains to be defined."