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Updated: Sep 21, 2025

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[Multiple sclerosis: what therapeutic perspectives ?]

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La Revue Du Praticien
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Multiple sclerosis disability stems from remyelination defects, chronic inflammation, and neurodegeneration. Future research aims to identify mechanisms and develop targeted therapies for multiple sclerosis.

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Area of Science:

  • Neuroscience
  • Immunology
  • Pharmacology

Background:

  • Multiple sclerosis (MS) is characterized by progressive accumulation of disability.
  • Key pathological features include impaired remyelination, persistent microglial inflammation, and neurodegeneration.
  • These factors are potentially interrelated and contribute to MS progression.

Purpose of the Study:

  • To explore therapeutic perspectives for multiple sclerosis (MS).
  • To identify molecular and cellular mechanisms underlying MS-related disability.
  • To advance in vivo tracking of these mechanisms using advanced imaging.

Main Methods:

  • Review of current understanding of MS pathophysiology.
  • Analysis of emerging translational pharmacological approaches.
  • Discussion of challenges in developing optimized methodologies and endpoints for clinical trials.

Main Results:

  • Multiple sclerosis disability is linked to remyelination defects, chronic microglial inflammation, and neurodegeneration.
  • Advanced imaging techniques are crucial for in vivo monitoring of disease mechanisms.
  • Several therapeutic strategies targeting these mechanisms are under investigation.

Conclusions:

  • Addressing remyelination defects, microglial activation, and neurodegeneration offers potential therapeutic avenues for MS.
  • Further research is needed to elucidate underlying mechanisms and refine therapeutic strategies.
  • Development of optimized methodologies and relevant endpoints is critical for successful clinical translation in MS treatment.