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An Acupoint Catgut-embedding Therapy for Treating Obesity

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Ertapenem Concentrations in Obese Patients Undergoing Surgery.

Seth T Housman¹, Peter B McWhorter², Philip S Barie³

¹Western New England University College of Pharmacy and Health Sciences, Springfield, Massachusetts, USA.

Surgical Infections

|May 31, 2022

Summary

Ertapenem prophylaxis may be effective for obese patients undergoing shorter surgeries. A single 1g dose demonstrated adequate drug concentrations for procedures up to four hours, particularly for susceptible bacteria.

Keywords:

ertapenem obesity surgical prophylaxis

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Published on: December 18, 2010

Area of Science:

Pharmacology
Infectious Disease
Surgical Science

Background:

Surgical site infections (SSIs) are a significant concern, especially in obese patients.
Ertapenem is a common antibiotic for surgical prophylaxis in gastrointestinal surgeries.

Purpose of the Study:

To characterize the population pharmacokinetics of ertapenem for surgical prophylaxis.
To evaluate the probability of target attainment (PTA) for ertapenem in obese surgical patients.

Main Methods:

A population pharmacokinetic model was developed from plasma samples of 10 patients receiving a single 1g intravenous dose of ertapenem.
Monte Carlo simulations were used to predict PTA for various minimum inhibitory concentrations (MICs).

Main Results:

The pharmacokinetic parameters included a half-life of 4.3 hours.
PTA exceeded 90% for MICs ≤0.125 mcg/mL for surgeries up to 4 hours.
Adequate PTA was not achieved for MICs ≥0.5 mcg/mL.

Conclusions:

A single 1g dose of ertapenem may be suitable for surgical prophylaxis in obese patients for procedures lasting up to four hours.
The effectiveness is dependent on the minimum inhibitory concentration of the targeted pathogen.