Intratumor microbiome in cancer progression: current developments, challenges and future trends.

Area of Science:

• Oncology
• Microbiology
• Immunology

Background:

• Cancer's complexity involves multifactorial changes, complicating treatment strategies.
• Infectious etiological factors, particularly microbiomes, are increasingly recognized for their role in carcinogenesis.
• While the gut microbiome's influence is well-studied, the intratumor microbiome's impact on cancer is gaining significant attention.

Purpose of the Study:

• To review the interplay between the intratumor microbiota and cancer.
• To elucidate the mechanisms by which the intratumor microbiome influences cancer initiation and progression.
• To explore potential therapeutic applications of targeting the intratumor microbiome.

Main Methods:

• Review of existing literature on intratumor microbiome research.
• Analysis of findings from clinical tumor samples, animal models, and in vitro studies.
• Synthesis of evidence on the role of intratumor microbes in tumorigenesis, immune evasion, and treatment response.

Main Results:

• The intratumor microbiome contributes to cancer initiation and progression.
• Intratumor microbes can induce cancerous epithelial cells and chronic inflammation.
• The intratumor microbiome influences immune evasion and modulates cancer treatment outcomes.

Conclusions:

• The intratumor microbiome is a critical factor in cancer development and progression.
• Targeting the intratumor microbiome presents a promising avenue for novel cancer therapies.
• Further research into the intratumor microbiome's mechanisms can lead to improved cancer treatment strategies.