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Ozone Therapy for Dermatological Conditions: A Systematic Review
Débora Aparecida Oliveira Modena1, Rafael de Castro Ferreira2, Patricia Meyer Froes3
1Dr. Oliveira Modena is with the Department of Surgery, Medical Sciences Institute, University of Campinas (Unicamp), Campinas, São Paulo, Brazil and the Departamento de Medicina Celular e Molecular, Faculdade de Medicina do ABC, Santo André, São Paulo, Brasil.
Ozone therapy shows potential for skin conditions, but current evidence is limited. More rigorous studies are needed to confirm its efficacy and safety for dermatological treatments.
Area of Science:
- Dermatology
- Medical Ozone Therapy
Background:
- Ozone, once known as an urban pollutant, is now recognized for potential antimicrobial, antiviral, and antioxidant benefits in dermatology.
- Despite reported clinical advantages, optimal ozone therapy dosage, application methods, and mechanisms of action remain unclear.
Purpose of the Study:
- To review the efficacy and safety of ozone therapy for various dermatological conditions.
Main Methods:
- Systematic review of randomized and non-randomized clinical trials published between December 2020 and March 2021.
- Included studies provided PICO (Population, Intervention, Outcome) information for conditions like acne, dermatitis, psoriasis, herpes, and skin scarring.
Main Results:
- 17 articles with 643 patients were included after screening 326 initial articles.
- Ozone therapy demonstrated promising results for certain dermatological conditions.
Conclusions:
- Current evidence for ozone therapy in dermatology is limited by methodological weaknesses.
- Further high-quality research with long-term safety assessments is necessary to establish standardized and safe therapeutic protocols.
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