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Updated: Sep 21, 2025

Synthesis of a Water-soluble Metal–Organic Complex Array
Published on: October 8, 2016
Redox- and metal-directed structural diversification in designed metalloprotein assemblies
Albert Kakkis1, Eyal Golub1, Tae Su Choi1
1Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. tezcan@ucsd.edu.
Abstract:
Herein we describe a designed protein building block whose self-assembly behaviour is dually gated by the redox state of disulphide bonds and the identity of exogenous metal ions. This protein construct is shown - through extensive structural and biophysical characterization - to access five distinct oligomeric states, exemplifying how the complex interplay between hydrophobic, metal-ligand, and reversible covalent interactions could be harnessed to obtain multiple, responsive protein architectures from a single building block.
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