Optical-based biosensor for detection of oncomarker CA 125, recent progress and current status.

Area of Science:

• Biomedical Engineering
• Analytical Chemistry
• Oncology

Background:

• Ovarian cancer (OV) is a leading cause of gynecological cancer mortality.
• CA 125 is a critical oncomarker for diagnosing early-stage ovarian cancer.
• Sensitive and real-time CA 125 detection is vital for effective ovarian cancer monitoring.

Purpose of the Study:

• To consolidate research on Surface Plasmon Resonance (SPR) biosensors for CA 125 detection over the past two decades.
• To review the advantages and challenges associated with SPR biosensor development for ovarian cancer diagnosis.
• To emphasize the significance of SPR biosensors in improving CA 125 oncomarker detection.

Main Methods:

• Literature review and synthesis of research on SPR biosensors for CA 125 detection.
• Analysis of recent advancements in biosensor technology for oncomarker analysis.
• Evaluation of the performance, sensitivity, and specificity of SPR-based diagnostic methods.

Main Results:

• Surface Plasmon Resonance (SPR) biosensors offer a promising platform for rapid, sensitive, and specific CA 125 detection.
• Significant progress has been made in developing SPR biosensors for ovarian cancer diagnostics.
• Challenges remain in optimizing SPR biosensor design and clinical applicability.

Conclusions:

• SPR biosensors represent a key advancement in ovarian cancer diagnostics through enhanced CA 125 detection.
• Continued research and development are crucial to overcome existing challenges and enhance clinical utility.
• SPR biosensor technology holds substantial potential for improving ovarian cancer patient outcomes.