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Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

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Related Experiment Video

Updated: Sep 21, 2025

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Published on: August 12, 2014

Mineralized vectors for gene therapy.

Teo A Dick¹, Eli D Sone², Hasan Uludağ³

¹Department of Chemical and Materials Engineering, Faculty of Engineering, University of Alberta, Edmonton, AB, Canada.

Acta Biomaterialia

|June 1, 2022

Summary

This summary is machine-generated.

Mineral-based materials offer safe and effective non-viral delivery of polynucleotides for gene therapy. Recent advances in synthesis and functionalization enhance their potential for clinical applications, improving gene medicine efficacy.

Keywords:

Calcium phosphate DNA and siRNA delivery Gene expression Mineralization Mineralized surfaces Nanoparticles Surface engineering

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Area of Science:

Biomaterials Science
Nanotechnology
Gene Therapy

Background:

Gene-based medicines are crucial for treating diseases unresponsive to conventional therapies.
Effective delivery of nucleic acids, essential for gene medicines, faces challenges due to their size and hydrophilicity.
Non-viral vectors, particularly mineral-based materials, are emerging as promising solutions for safe and efficient gene delivery.

Purpose of the Study:

To review recent advancements in the chemical synthesis, physicochemical properties, and applications of mineralized materials for gene therapy.
To explore the structure-function relationships of mineralized vectors, focusing on controlled mineralization and surface functionalization.
To provide a perspective on the future of mineralized vectors in gene delivery.

Main Methods:

Review of literature on mineralized materials for gene delivery, including synthesis techniques and characterization methods.
Analysis of calcium phosphate-derived vectors and comparison with other mineral systems.
Critical evaluation of advanced mineral vectors, templated mineralization, and multicomponent systems.

Main Results:

Significant progress has been made in controlling mineral growth and surface functionalization for enhanced vector performance.
Mineralized vectors, especially those based on calcium phosphate, demonstrate tunable properties for effective gene delivery.
Emerging synthesis technologies enable the development of new-generation mineral vectors with improved biocompatibility and controlled dissolution.

Conclusions:

Mineral-based materials represent a promising class of non-viral vectors for gene therapy, offering safety and efficacy.
Further research into controlled synthesis, structure-function relationships, and complex mineral systems will advance their clinical translation.
Mineralized vectors hold significant potential for the future of gene medicine, addressing current delivery challenges.