Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Preclinical Development: Overview

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...

Clinical Trials: Overview

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Toll-like Receptor 4 Knockout Mice are Protected Against PMOS-like Pathogenesis.

Reproduction (Cambridge, England)·2026

Same author

Infection of 5xFAD mice with a mouse-adapted SARS-CoV-2 does not alter Alzheimer's disease neuropathology yet induces widespread changes in gene expression across diverse cell types.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same author

Systems genetics reveals ITIH5 as a key mediator of adipocyte-Endothelial crosstalk.

Molecular metabolism·2026

Same author

The Kaposi's sarcoma-associated herpesvirus viral genome packaging accessory factor ORF68 forms cytoplasmic puncta dependent on the viral tyrosine kinase.

bioRxiv : the preprint server for biology·2026

Same author

Luminal epithelium remodeling underlies endometrial regeneration during menstruation and pregnancy.

bioRxiv : the preprint server for biology·2026

Same author

PFKM governs metabolic shifts throughout skeletal muscle differentiation.

Nature metabolism·2026

Same journal

Peptideins: Navigating the gray zone of the proteome.

Trends in biochemical sciences·2026

Same journal

A metabolon channels nicotine biosynthesis.

Trends in biochemical sciences·2026

Same journal

Better call chaperone.

Trends in biochemical sciences·2026

Same journal

Biochemistry at scale: Seeing both the forest and the trees.

Trends in biochemical sciences·2026

Same journal

Voices across Asia and Oceania: Biochemistry across borders.

Trends in biochemical sciences·2026

Same journal

Metabolic control of RNA splicing by polyamines.

Trends in biochemical sciences·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 21, 2025

Remote Laboratory Management: Respiratory Virus Diagnostics

Remote Laboratory Management: Respiratory Virus Diagnostics

Published on: April 6, 2019

The transition phase: preparing to launch a laboratory.

Kara L McKinley¹, Allison L Didychuk², Dequina A Nicholas³

¹Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.

Trends in Biochemical Sciences

|June 1, 2022

Summary

This summary is machine-generated.

Launching a new laboratory involves universal tasks for all principal investigators. This guide centralizes essential information for new group leaders, simplifying the laboratory startup process.

Keywords:

career development career transitions faculty group leaders management

More Related Videos

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 1. Biosafety Level 4 Suit Laboratory Suite Entry and Exit Procedures

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 1. Biosafety Level 4 Suit Laboratory Suite Entry and Exit Procedures

Published on: October 3, 2016

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 2. General Practices

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 2. General Practices

Published on: October 3, 2016

Related Experiment Videos

Last Updated: Sep 21, 2025

Remote Laboratory Management: Respiratory Virus Diagnostics

Remote Laboratory Management: Respiratory Virus Diagnostics

Published on: April 6, 2019

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 1. Biosafety Level 4 Suit Laboratory Suite Entry and Exit Procedures

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 1. Biosafety Level 4 Suit Laboratory Suite Entry and Exit Procedures

Published on: October 3, 2016

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 2. General Practices

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 2. General Practices

Published on: October 3, 2016

Area of Science:

Laboratory Management
Scientific Research
Academic Science

Background:

Starting a new research laboratory presents unique challenges.
Institutional processes for laboratory setup can differ significantly.
Incoming group leaders require a consolidated resource for essential startup information.

Purpose of the Study:

To provide a centralized summary of key considerations for launching a new laboratory.
To assist new principal investigators in navigating the complexities of laboratory startup.
To offer a foundational resource for the scientific community establishing research groups.

Main Methods:

Literature review of best practices in laboratory management.
Synthesis of common requirements for establishing a research group.
Compilation of essential administrative and logistical tasks.

Main Results:

Identification of universal tasks applicable across different institutions for laboratory startup.
A structured overview of critical considerations for new group leaders.
Centralization of information to streamline the laboratory initiation process.

Conclusions:

Successful laboratory launch requires addressing a core set of universal tasks.
This resource aims to simplify and expedite the process for new investigators.
Effective planning and resource centralization are crucial for establishing a new research laboratory.