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A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles
Published on: March 20, 2019
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Recent Advances in Aptamer-Based Nanopore Sensing at Single-Molecule Resolution.
Pengrui Lv1, Wenxin Zhang1, Yongyi Yang1
1Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, P. R. China.
Chemistry, an Asian Journal
|June 1, 2022
Summary
Aptamer-based nanopore sensors offer sensitive detection for various applications. This review highlights advances in aptamer selection, nanopore types, and sensing strategies for single-molecule analysis.
Area of Science:
- Biotechnology
- Nanotechnology
- Analytical Chemistry
Background:
- Aptamers are increasingly used as recognition elements in nanopore sensors.
- Nanopore sensing offers label-free, single-molecule detection capabilities.
Purpose of the Study:
- To review recent advances in aptamer-based nanopore sensing techniques.
- To discuss applications and future perspectives of these sensors.
Main Methods:
- Classification and selection of various nanopore types (biological, solid-state, nanopipettes).
- Exploration of different aptamer-based sensing strategies.
- Application of single-molecule nanopore sensors to study aptamer-target interactions.
Main Results:
- Aptamer-based nanopore sensors demonstrate high selectivity and sensitivity.
- Single-molecule analysis reveals details of aptamer-target binding kinetics and orientation.
- Successful applications in environmental analysis, diagnostics, pharmaceuticals, and security.
Conclusions:
- Aptamer-based nanopore sensing is a rapidly advancing field with significant potential.
- Further development of these sensors will enhance precision diagnostics and other applications.
