Related Experiment Video
Updated: Sep 21, 2025
Establishing a Silicosis Rat Model via Exposure of Whole-Body to Respirable Silica
Published on: October 28, 2022
Extended Investigation of Exposure to Respirable Synthetic Amorphous Silica Dust and Its Potential Impact on
Mei Yong1, Peter Morfeld2, Robert McCunney3
1MY EpiConsulting, Duesseldorf, Germany.
Objectives:
The present analysis aims to study the health impact of an occupational exposure to respirable synthetic amorphous silica (SAS) dusts, based on the available data from the German study.
Methods:
The effect of cumulative exposure to respirable SAS dust on respiratory morbidity were investigated in 462 exposed male workers. Multiple exposure assessments was performed anchored by a most recent measurement series. Internal regression models in addition to Monte Carlo-Multi Model were fitted.
Results:
An averaged cumulative respirable SAS dust concentration of 6.44 mg/m3-years was estimated. Internal regression models suggested a reduction of 8.11 ml (95% confidence interval: 0.49-15.73) in forced vital capacity (FVC) per 1 mg/m3-year increase of exposure. But no effect on forced expiratory volume in 1 s (FEV1) and the ratio of the parameters FEV1/FVC was observed in association with exposure to a respirable fraction of SAS. No adverse effects on the occurrence of respiratory diseases were indicated.
Conclusion:
This study provides no clear evidence of adverse health effects from occupational exposure to respirable SAS.
Sponsor:
Evonik Operations GmbH/Smart Materials, Cabot Corporation, Wacker Chemie AG.
