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Inflammatory Microenvironment Accelerates Bone Marrow Mesenchymal Stem Cell Aging.

Xin Peng1,2,3, Xin Zhou1,2,3, Ying Yin1,2,3

  • 1Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Bioengineering and Biotechnology
|June 1, 2022
PubMed
Summary
This summary is machine-generated.

Aging bone marrow mesenchymal stem cells (BMSCs) create an inflammatory environment that impairs young BMSCs. Targeting this inflammation may improve stem cell therapy for age-related bone diseases.

Keywords:
agingaging-related skeletal diseasesbone marrow mesenchymal stem cellinflammatory microenvironmentstem cell therapy

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Area of Science:

  • Gerontology
  • Stem Cell Biology
  • Immunology

Background:

  • Mesenchymal stem cell (MSC) senescence contributes to age-related diseases.
  • Understanding the impact of the aging inflammatory microenvironment on MSCs is crucial for developing effective therapies.

Purpose of the Study:

  • To investigate how the inflammatory microenvironment affects bone marrow mesenchymal stem cells (BMSCs) in aging.
  • To elucidate the underlying mechanisms for potential stem cell therapy strategies for age-related osteoporosis.

Main Methods:

  • Cultured young and aged BMSCs in vitro, collecting conditioned medium (CM).
  • Treated young BMSCs with CM from different aged groups to assess effects on aging and stemness.
  • Analyzed serum inflammation profiles in young and old mice using a mouse inflammation array.
  • Utilized Gene Ontology (GO) and KEGG pathway analyses to explore underlying mechanisms.

Main Results:

  • CM from senescent MSCs altered the physiology of young BMSCs.
  • Aging mice exhibited altered systemic inflammatory microenvironments, with increased IL-6 and decreased IL-10.
  • The JAK-STAT signaling pathway, linked to IL-6 and IL-10, showed alterations.

Conclusions:

  • The age-related inflammatory microenvironment significantly impacts BMSC biological functions.
  • Targeting and reversing this inflammatory environment presents a potential therapeutic strategy for age-related skeletal diseases using stem cells.