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[Changes in the hemostatic function of muscle tissue in phylogenesis]
Zhurnal Evoliutsionnoi Biokhimii I Fiziologii
|January 1, 1987
Summary
Muscle tissue extracts from diverse animals reveal complex coagulating and fibrinolytic activities. Progressive evolution shows reduced anticoagulation and enhanced thromboplastic activity in muscle hemostasis.
Area of Science:
- Comparative physiology
- Biochemistry
- Hemostasis
Context:
- Muscle tissue harbors intrinsic mechanisms regulating blood clotting and clot breakdown.
- Investigating diverse animal models provides insights into evolutionary adaptations of hemostatic functions.
Purpose:
- To analyze the coagulating and fibrinolytic properties of muscle tissue across a range of animal species.
- To identify the presence of activators, inhibitors, and antiheparin factors within muscle extracts.
Summary:
- Muscle extracts from earthworm, clam, car, frog, pigeon, and rat contain both procoagulant and fibrinolytic factors.
- These extracts demonstrated antiheparin activity, influencing the blood clotting cascade.
- Findings indicate a trend towards decreased anticoagulation and increased thromboplastic activity with evolutionary progression.
Impact:
- Elucidates the evolutionary trajectory of hemostatic mechanisms in muscle tissue.
- Provides a basis for understanding the biochemical basis of muscle-derived hemostatic factors.
- Contributes to the broader knowledge of comparative hematology and evolutionary biology.