Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Leveraging Clinical Data Warehouses to Detect Potential False-Negatives EBV Patients Automatically.

Studies in health technology and informatics·2026
Same author

Corrigendum to "A new SARS-CoV-2 variant with high lethality poorly detected by RT-PCR on nasopharyngeal samples: an observational study" [Clin Microbiol Infect 28 (2) (2022) 298.e9-e15].

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2026
Same author

Artificial intelligence and machine learning for plasmonic and surface-enhanced sensing.

Chemical Society reviews·2026
Same author

Clinical Phenotypes of Critically Ill Patients with COVID-19 Infected with Omicron: A Nationwide Prospective Cohort Study.

Infectious diseases and therapy·2026
Same author

Intracranial Surface-Enhanced Raman Scattering Endoscopy for <i>In Vivo</i> Protein Quantification under Physiological Stimulation.

ACS sensors·2025
Same author

Profile, Infection, and Vaccination Uptake: A Cohort of Canadian Retail Workers During the SARS-CoV-2 Pandemic.

Infectious disease reports·2025

Related Experiment Video

Updated: Sep 21, 2025

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs
03:33

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs

Published on: November 17, 2023

2.6K

Combining multilayered wrinkled polymer SERS substrates and spectral data processing for low concentration analyte

Benjamin Charron1, Vincent Thibault1, Jean-Francois Masson2

  • 1Département de Chimie, Quebec Center for Advanced Materials, Regroupement Québécois Sur Les Matériaux de Pointe, and Centre Interdisciplinaire de Recherche Sur Le Cerveau Et L'apprentissage, Université de Montréal, CP. 6128 Succ. Centre-Ville, Montréal, QC, H3C 3J7, Canada.

Analytical and Bioanalytical Chemistry
|June 1, 2022
PubMed
Summary

This study developed advanced surface-enhanced Raman scattering (SERS) substrates using bimetallic gold and silver films with gold nanoparticles (AuNPs). These optimized SERS sensors significantly enhance dopamine detection sensitivity through synergistic amplification methods.

Keywords:
Chemical sensorsIR spectroscopyNanoparticlesNanotechnologyRaman spectroscopy

More Related Videos

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

20.6K
A Filter-based Surface Enhanced Raman Spectroscopic Assay for Rapid Detection of Chemical Contaminants
08:13

A Filter-based Surface Enhanced Raman Spectroscopic Assay for Rapid Detection of Chemical Contaminants

Published on: February 19, 2016

9.5K

Related Experiment Videos

Last Updated: Sep 21, 2025

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs
03:33

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs

Published on: November 17, 2023

2.6K
Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

20.6K
A Filter-based Surface Enhanced Raman Spectroscopic Assay for Rapid Detection of Chemical Contaminants
08:13

A Filter-based Surface Enhanced Raman Spectroscopic Assay for Rapid Detection of Chemical Contaminants

Published on: February 19, 2016

9.5K

Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Nanotechnology

Background:

  • Surface-enhanced Raman scattering (SERS) is a powerful technique for detecting low-concentration analytes.
  • Enhancing SERS signal intensity is crucial for sensitive and reliable detection.
  • Combining multiple SERS amplification strategies can lead to synergistic effects.

Purpose of the Study:

  • To investigate the synergistic effects of various SERS amplification methods for enhanced dopamine detection.
  • To develop highly sensitive SERS substrates using bimetallic films and gold nanoparticles (AuNPs).
  • To optimize SERS sensor performance for low-concentration dopamine analysis.

Main Methods:

  • Preparation of thermally shrinkable polymer SERS substrates with bimetallic Au/Ag films.
  • Incorporation of gold nanoparticles (AuNPs) at different positions within the layered structure.
  • Evaluation of signal enhancement from bimetallic layers, oxidized silver, surface wrinkling, and AuNPs.

Main Results:

  • Bimetallic Au/Ag films enhanced Raman signals 5-2 times compared to single layers.
  • Oxidizing silver and adding AuNPs further boosted signal intensity by factors of 2 and 10, respectively.
  • Combining wrinkling, AuNPs, and a silver underlayer improved SERS intensity by over three orders of magnitude, demonstrating significant synergistic effects.

Conclusions:

  • Synergistic combination of SERS amplification methods offers superior signal enhancement for dopamine detection.
  • Optimized SERS substrates show potential for sensitive and reliable detection of low-concentration dopamine.
  • Developed software aids in processing SERS data and identifying detection events.