Related Experiment Video
Updated: Sep 21, 2025

Customization of Aspergillus niger Morphology Through Addition of Talc Micro Particles
Published on: March 15, 2012
Formation of Azaphilone Pigments and Monasnicotinic Acid by the Fungus Aspergillus cavernicola
Tatiana V Antipova1, Valentina Zhelifonova1, Kirill V Zaitsev2
1FSBIS FRC Pushchino Scientific Centre of Biological Research, Russian Academy of Sciences, G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms RAS, Pushchino 142290, Russian Federation.
Abstract:
Due to the ever-increasing demand for healthy and safe food, much attention has been gained by natural food colorants. This study showed the culture fluid extract of the fungus Aspergillus cavernicola VKM F-906 to contain red pigment and monasnicotinic acid (MNA) in predominant amounts. The structure of the pigment corresponded to cis-cavernamine (red pigment, RP). Two tautomers, NH and OH forms, in rapid equilibrium were present in a solution of RP. The critical factors for RP to form were the presence of NH4+ salt and pH 6.3-6.5. In vitro experiments showed that MNA was synthesized from RP as a result of chemical transformations without the participation of enzymes. In this case, the main influence on the reaction rate is exerted by the pH of the medium, which is associated with the keto-enol tautomerism of RP in solution. The culture broth extract and MNA exhibited antifungal activity against Fusarium fungi.
More Related Videos
07:12Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
09:21Inhibition of Aspergillus flavus Growth and Aflatoxin Production in Transgenic Maize Expressing the α-amylase Inhibitor from Lablab purpureus L.
Published on: February 15, 2019
Related Concept Videos
Fungal Phylum Ascomycota
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Fungal Group Zygomycota
Fungal Phylum Basidiomycota
Bacterial Phylum Actinobacteria
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview