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Updated: Sep 21, 2025
Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
Published on: April 21, 2023
Antibacterial activity of guanidinium-based ionic covalent organic framework anchoring Ag nanoparticles
Hongxu Zhang1, Jing Ma1, Chong Liu1
1School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, PR China; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
Abstract:
In this paper, the antibacterial 2D covalent organic framework (COFTGTp) containing guanidyl cation was synthesized and used as a carrier to deposit AgNPs on N and O groups to form nanocomposites to avoid AgNPs aggregation and achieve excellent antibacterial effect. The Ag content in Ag/COFTGTp was 10.3% determined by ICP. TEM can clearly observe that AgNPs were uniformly dispersed in COFTGTp. Ag/COFTGTp was stable after being evenly dispersed in water with low cytotoxicity and hemolysis rate to erythrocytes. In bacteriostatic study, the minimum inhibitory concentration of Ag/COFTGTp for E. coli and S. aureus were 100 μg/mL and 50 μg/mL, respectively. Finally, the morphology of the bacteria was observed by SEM, confirmed the main sterilization by Ag/COFTGTp was destroying the cell wall of the bacteria.
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