Application of metal-organic framework-based reactive oxygen species therapy in cancer

Area of Science:

• Nanomedicine
• Biomedical Engineering
• Materials Science

Background:

• Reactive oxygen species (ROS) show therapeutic potential in cancer treatment.
• Metal-organic frameworks (MOFs) are emerging as effective nanocarriers for ROS-mediated therapies.
• MOFs offer advantages in synthesis, structure, and biological applications for cancer treatment.

Purpose of the Study:

• To systematically review the advantages and applications of MOFs in ROS-mediated cancer therapy.
• To explore the mechanisms by which MOFs modulate the tumor microenvironment via ROS.
• To discuss the potential of MOF-based ROS therapies in combination and synergistic anticancer strategies.

Main Methods:

• Systematic literature review of MOF-based ROS therapies in cancer.
• Analysis of MOF synthesis, structure, and biological properties relevant to ROS generation.
• Evaluation of MOF mechanisms, including Fenton/Fenton-like reactions and enzyme-like activity.
• Investigation of synergistic and combination therapeutic approaches using MOFs and ROS.

Main Results:

• MOFs demonstrate significant advantages as nanocarriers for ROS generation in cancer treatment.
• MOFs effectively modulate the tumor microenvironment through Fenton reactions and enzyme mimicry.
• Combination therapies involving MOF-augmented ROS show enhanced therapeutic effects and synergistic potential.

Conclusions:

• MOF-based nanocarriers are a promising platform for developing novel ROS-mediated cancer therapies.
• Understanding MOF mechanisms and synergistic strategies is crucial for advancing nanomedicine in oncology.
• This review serves as a reference for developing innovative MOF-based anticancer nanomedicines and accelerating biomedical innovation.