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Updated: Sep 21, 2025

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

Precise Placement of Microbubble Templates at Single Entity Resolution.

Ji Tae Kim¹, Jaeyeon Pyo², Seung Kwon Seol^2,3

¹Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China.

ACS Macro Letters

|June 2, 2022

Summary

This summary is machine-generated.

Researchers developed a new method to precisely control microbubble size and position for fabricating hollow structures. This technique uses a scanning micropipette to place hydrogen bubbles, enabling advanced applications in materials science and biomedicine.

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Introduction to the Ultrasound Targeted Microbubble Destruction Technique

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Last Updated: Sep 21, 2025

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Introduction to the Ultrasound Targeted Microbubble Destruction Technique

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Published on: June 12, 2011

Area of Science:

Materials Science
Chemistry
Biomedicine

Background:

Microbubbles serve as soft templates for creating hollow structures.
Controlling microbubble size and position at the single-entity level remains a challenge.

Purpose of the Study:

To develop an on-demand method for producing and positioning single microbubbles with programmed size.
To demonstrate the utility of precisely controlled microbubbles in fabricating polypyrrole microcontainer arrays.

Main Methods:

Utilized a scanning electrolyte-filled micropipette to place hydrogen (H2) bubbles generated by water electrolysis.
Employed phase-contrast X-ray imaging and electric-current measurement to investigate bubble growth dynamics.
Achieved self-limited bubble growth by matching bubble size to the pipette aperture for size control.

Main Results:

Successfully produced and positioned single microbubbles with programmed size and location.
Demonstrated the fabrication of polypyrrole microcontainer arrays using these controlled microbubbles.
Investigated and understood the bubble growth dynamics within the pipette.

Conclusions:

The scanning-pipet strategy offers precise control over microbubble size and position.
This method is effective for fabricating hollow structures like polypyrrole microcontainers.
The technique holds potential for broader applications in manipulating soft materials.