Synthesis of Fluorescent Sulfur Quantum Dots for Bioimaging and Biosensing

The rapid industrialization has had a serious impact on the environment, leading to an increase in disease and healthcare problems. The development of simple and effective biosensors to achieve specific analyte detection and bioimaging can provide useful information for disease prevention and treatment. Sulfur quantum dots (SQDs), a new class of metal-free fluorescent nanomaterial, are being studied and applied in diagnostic fields such as bioimaging and biosensing due to their advantages of simple synthetic process, unique composition, ultrasmall size, adjustable fluorescence, and low toxicity. This minireview highlights the main synthetic methods to synthesize fluorescent SQDs and their recent progress in cell and tissue imaging, as well as detection of biomolecules, metal ions, and temperature. Finally, the future development and some critical challenges of SQDs as a fluorescent probe in the field of bioimaging and biosensing are also discussed.