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Cardiac Action Potential

Cardiac Action Potential

Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials

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Related Experiment Video

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In Silico Clinical Trials for Cardiovascular Disease

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Intracardiac Inverse Potential Mapping Using the Method of Fundamental Solutions.

Shu Meng¹, Nicholas Sunderland^1,2, Judit Chamorro-Servent³

¹Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.

Frontiers in Physiology

|June 2, 2022

Summary

Noncontact mapping accurately reconstructs atrial fibrillation (AF) potentials using a novel inverse mapping technique. This method enables real-time panoramic potential mapping for improved ablation target identification.

Keywords:

atrial arrhythmia endocardial potentials inverse mapping method of fundamental solutions multi-electrode basket catheters

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Published on: January 31, 2019

Area of Science:

Electrophysiology
Computational Cardiology
Medical Imaging

Background:

Atrial fibrillation (AF) is a common arrhythmia requiring catheter ablation.
Current panoramic mapping methods using multi-electrode catheters have limitations in contact and coverage.
Accurate identification of ablation targets is crucial for effective AF treatment.

Purpose of the Study:

To evaluate the accuracy of inverse mapping for reconstructing endocardial surface potentials using noncontact basket catheters.
To assess the feasibility of real-time 3D potential mapping in persistent AF.

Main Methods:

Development of a computationally efficient inverse 3D mapping technique using the Method of Fundamental Solutions (MFS).
Utilized an in-silico test bed comparing ground-truth potentials with inverse maps from virtual catheter recordings.
Ground-truth potentials were derived from high-density contact mapping data and computer models.

Main Results:

The MFS-based inverse solutions demonstrated robustness, speed, and accuracy.
Real-time reconstruction of endocardial surface potentials is achievable with known cardiac geometry and electrode positions.
Larger catheters with adequate electrode density are necessary for mapping complex reentrant atrial rhythms.

Conclusions:

Real-time panoramic potential mapping is feasible using noncontact intracardiac catheters and the MFS.
Accurate endocardial potential maps can be reconstructed in AF patients with optimized noncontact multi-electrode catheter designs.