Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The use of map functions in multipoint mapping.

L Pascoe, N E Morton

    American Journal of Human Genetics
    |February 1, 1987
    PubMed
    Summary

    This study generalizes predictive formulas for multiple recombination frequencies, improving genetic map accuracy. New map functions offer better fits to experimental data than previous models.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Longitudinal Preterm Cerebellar Volume: Perinatal and Neurodevelopmental Outcome Associations.

    Cerebellum (London, England)·2018
    Same author

    Molecular biology of 11β-hydroxylase and 11β-hydroxysteroid dehydrogenase enzymes.

    The Journal of steroid biochemistry and molecular biology·2012
    Same author

    Increased maternal Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) associated with older age at diagnosis of Type 1 diabetes in offspring.

    Diabetic medicine : a journal of the British Diabetic Association·2010
    Same author

    RIP2 polymorphisms in inflammatory bowel diseases.

    Inflammatory bowel diseases·2010
    Same author

    Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response.

    Diabetologia·2009
    Same author

    TNFSF15 polymorphisms are associated with susceptibility to inflammatory bowel disease in a new European cohort.

    The American journal of gastroenterology·2009

    Area of Science:

    • Genetics
    • Bioinformatics
    • Computational Biology

    Background:

    • Multipoint analysis in human genetics requires accurate prediction of recombination frequencies.
    • Existing models often rely on simplifying assumptions that may not reflect biological reality.

    Purpose of the Study:

    • To generalize predictive formulas for multiple recombination frequencies using realistic map functions.
    • To identify and propose improved map functions for genetic analysis.

    Main Methods:

    • Generalization of the Markovian assumption for multiple-region recombination.
    • Fitting proposed map functions to empirical genetic data from Drosophila melanogaster.
    • Comparison of novel map functions against established models.

    Main Results:

    • Two map functions, Rao et al. and a newly proposed function, demonstrated superior fit to Drosophila X chromosome data.
    • The estimated mapping parameter aligns with human male meiosis data, suggesting robustness.
    • A two-parameter model further enhanced data fit by accounting for multiple recombinants.

    Conclusions:

    • The developed map functions provide more accurate predictions for genetic mapping.
    • The findings challenge the 'no interference' assumption, highlighting its inadequacy for complex genetic data.
    • This work contributes to more precise genetic linkage analysis and map construction.

    Related Experiment Videos