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NAD+ and Vascular Dysfunction: From Mechanisms to Therapeutic Opportunities
Mahmoud Abdellatif1,2,3, Heiko Bugger1, Guido Kroemer2,3,4
1Department of Cardiology, Medical University of Graz, Graz, Austria.
Journal of Lipid and Atherosclerosis
|June 3, 2022
Summary
Boosting nicotinamide adenine dinucleotide (NAD+) levels shows promise for vascular health. NAD+ repletion therapy may combat age-related cardiovascular and cerebrovascular disorders by reducing inflammation and improving metabolism.
Area of Science:
- Biochemistry and Molecular Biology
- Cardiovascular Research
- Aging Research
Background:
- Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme in cellular metabolism, signaling, and epigenetic regulation.
- Vascular disease is linked to abnormal NAD+ metabolism.
- NAD+ plays a critical role in maintaining vascular health.
Purpose of the Study:
- To review NAD+-regulated mechanisms essential for vascular health.
- To summarize advances in NAD+ research concerning vascular aging and diseases.
- To explore the potential of NAD+ repletion therapy for vascular medicine.
Main Methods:
- Literature review of NAD+ metabolism and vascular health.
- Analysis of studies on NAD+ precursors and inhibitors in vascular pathologies.
- Examination of research on NAD+ in hypertension, atherosclerosis, and other vascular diseases.
Main Results:
- Therapeutic increases in NAD+ levels reduce inflammation and enhance oxidative metabolism in vascular cells.
- NAD+ repletion strategies show potential in preclinical models of vascular disease.
- NAD+ is implicated in key pathways regulating vascular aging.
Conclusions:
- NAD+ is a promising therapeutic target for age-related cardiovascular and cerebrovascular disorders.
- NAD+ repletion therapy presents challenges and opportunities for future clinical applications.
- Further research into NAD+ metabolism will significantly impact vascular medicine.
Keywords:
AgingAutophagyHypertensionInflammationMitochondriaNicotinamide adenine dinucleotideVascular diseaseMore Related Videos
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