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Updated: Sep 21, 2025

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
Published on: July 11, 2025
Ongoing monkeypox virus outbreak, Portugal, 29 April to 23 May 2022
Mariana Perez Duque1, Sofia Ribeiro1,2, João Vieira Martins1
1Directorate of Information and Analysis, Directorate-General of Health, Lisbon, Portugal.
Portugal reported 96 monkeypox cases by May 2022. Analysis of 27 cases suggests potential undetected community spread, as most lacked clear transmission links or travel history.
Area of Science:
- Epidemiology
- Infectious Diseases
- Public Health
Background:
- Monkeypox (MPX) is a viral zoonotic disease with potential for human-to-human transmission.
- Global outbreaks of monkeypox have raised public health concerns.
- Portugal reported its first cases in early 2022.
Purpose of the Study:
- To characterize the initial monkeypox cases in Portugal.
- To investigate potential transmission routes and epidemiological patterns.
Main Methods:
- Descriptive epidemiological analysis of confirmed monkeypox cases.
- Review of clinical data, symptom onset, and exposure history.
Main Results:
- As of May 27, 2022, Portugal confirmed 96 monkeypox cases.
- A detailed analysis of 27 cases (median age 33, all male) revealed symptom onset from April 29.
- The majority of cases (25/27) resided in the Lisbon and Tagus Valley region.
- Most cases had no identified transmission chains, travel history, or contact with symptomatic individuals or animals.
Conclusions:
- The findings suggest a possible undetected community spread of monkeypox in Portugal.
- Further investigation into non-traditional transmission routes may be warranted.
- Enhanced surveillance and contact tracing are crucial for controlling monkeypox outbreaks.
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