CircadiOmics: circadian omic web portal.

Area of Science:

• Biology
• Chronobiology
• Bioinformatics

Background:

• Circadian rhythms are endogenous biological processes influencing molecular, cellular, and physiological functions.
• Research into circadian rhythms is expanding rapidly due to their fundamental role in homeostasis.
• High-throughput omics data is crucial for understanding complex circadian patterns.

Purpose of the Study:

• To introduce CircadiOmics, a comprehensive repository and analysis web server for omics circadian time series data.
• To provide researchers with a centralized platform for accessing and analyzing large-scale circadian datasets.
• To facilitate the study of molecular oscillations and their role in biological systems.

Main Methods:

• The CircadiOmics database aggregates data from over 290 experiments.
• It includes more than 100 million measurements across diverse tissues, organs, and species.
• Data analysis involves deriving and comparing periodicity statistics (period, amplitude, phase, P-value, q-value) using BIO_CYCLE and JTK_CYCLE.

Main Results:

• CircadiOmics hosts the largest annotated repository of omics circadian time series data.
• It enables visualization and mining of datasets for over 20 unique tissues/organs and 11 species.
• Periodicity statistics are aggregated and displayed for comparative analysis of oscillating molecular species.

Conclusions:

• CircadiOmics serves as a cutting-edge web portal for circadian omics research.
• It supports global researchers by providing extensive data and analytical tools.
• The platform advances the understanding of biological rhythms and their impact on health and disease.