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Published on: January 27, 2019
[Probiotics in asthma treatment]
C Moermans1,2, S Graff1,2, S Gerday1
1Groupe de Recherche GIGA I3, ULiège, Belgique.
Insights
Probiotics may offer new therapeutic approaches for asthma by modulating the gut microbiome. This review explores their potential in asthma prevention and treatment due to their anti-inflammatory properties.
Area of Science:
- Immunology
- Microbiology
- Respiratory Medicine
Background:
- Asthma is a widespread chronic inflammatory airway disease.
- Gut microbiota dysregulation is linked to immune development and asthma emergence.
- Alterations in intestinal microbiota are observed in individuals with asthma.
Purpose of the Study:
- To review the current knowledge on probiotic use for asthma.
- To explore probiotics as potential therapeutic agents for asthma.
Main Methods:
- Literature review of studies on probiotics and asthma.
- Analysis of the role of gut microbiota in asthma pathogenesis.
- Evaluation of probiotic properties, including anti-inflammatory and immunoregulatory effects.
Main Results:
- Probiotics can modulate the gut microbiome.
- Probiotics demonstrate anti-inflammatory and immunoregulatory properties.
- Probiotics are generally well-tolerated and safe.
Conclusions:
- Probiotic use in asthma prevention and treatment is a promising area.
- Probiotics may offer novel therapeutic perspectives for managing asthma.
- Further research is warranted to fully elucidate the role of probiotics in asthma.
Abstract:
Asthma is the most prevalent chronic inflammatory airway disease worldwide. The gut microbiota possesses an important link with the development of the immunity in youth and a dysregulation of the gut flora was implicated in the asthmatic disease emergence. Moreover, a dysregulation of the intestinal microbiota exists in asthmatic individual. Probiotics are micro-organisms that can regulate our microbiome conferring potential beneficial effects on health. Thereby, their use in asthma prevention and treatment is attractive and could lead to new therapeutic perspectives. Indeed, they are well tolerated and safe and possess anti-inflammatory and immunoregulatory properties. This article is intended to update the current state of knowledge regarding the use of probiotics in the context of asthma.
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