[Atherosclerosis, an inflammatory disease]

Area of Science:

• Cardiovascular Science
• Immunology
• Pathology

Background:

• Chronic inflammation is a key factor in atherosclerosis, influencing its development, progression, and complications.
• Atherosclerosis exhibits an inflammatory nature, evidenced by inflammatory cells, cytokines, and chemokines throughout disease stages.
• Serum inflammatory markers like C-reactive protein (CRP), Interleukin-6 (IL-6), and Interleukin-1 beta (IL-1β) are linked to cardiovascular events.

Purpose of the Study:

• To detail the involvement of inflammatory processes in atherosclerosis.
• To review advancements in therapeutic strategies targeting inflammation in atherosclerosis.

Main Methods:

• Review of scientific literature on inflammation and atherosclerosis.
• Analysis of the role of specific inflammatory markers and pathways.
• Examination of current and emerging therapeutic approaches.

Main Results:

• Confirmation of chronic inflammation's central role in all phases of atherosclerosis.
• Established association between cardiovascular events and elevated inflammatory markers.
• Identification of inflammasome pathway involvement in producing key inflammatory mediators.

Conclusions:

• Inflammation is integral to atherosclerosis pathogenesis and complications.
• Therapeutic strategies targeting inflammatory pathways show promise for managing atherosclerosis.
• Further research into anti-inflammatory treatments is crucial for cardiovascular health.