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Exploring Synthesis and Chemotherapeutic Potential of Thiosemicarbazide Analogs

Akhalesh Kumar1, Rakhi Mishra1, Avijit Mazumder1

  • 1Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Knowledge park-2, Plot 19, Greater Noida, India.

Anti-Cancer Agents in Medicinal Chemistry
|June 6, 2022
PubMed
Abstract

Insights

Thiosemicarbazide analogs show emerging potential as anticancer agents. Further clinical trials are needed to confirm their efficacy in cancer treatment.

Area of Science:

  • Medicinal Chemistry
  • Oncology

Background:

  • Cancer remains a leading global cause of mortality, driving the search for novel therapeutic agents.
  • Thiosemicarbazide analogs are being investigated for their potential anticancer properties.

Approach:

  • A systematic literature review analyzed research from the past 15 years.
  • The review focused on the synthesis and anticancer activity of thiosemicarbazide analogs against various cancer targets.

Key Points:

  • Several novel synthetic routes for thiosemicarbazide derivatives have been reported.
  • These analogs demonstrate potential in targeting various cancer types.

Conclusions:

  • Thiosemicarbazide analogs represent a promising area for cancer drug development.
  • Lack of clinical trial data is a significant limitation for their translation into new cancer medications.
Keywords:
Thiosemicarbazidecancerclinical trialdiseasessynthesistarget

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