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Nanomedicine: controlling nanoparticle clearance for translational success
Geyunjian Harry Zhu1, Alex B C Gray2, Hirak K Patra2
1Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
None:
Achieving complete nanoparticle (NP) clearance is a key consideration in the design of safe and translatable nanomedicines. Renal-clearable nano formulations must encompass the beneficial nanoscale functionalities whilst exhibiting clearance profiles like those of small-molecule therapeutics. Recent developments in the field have enabled the growth of novel renal-clearable NPs with transformable sizes that take advantage of alternative clearance mechanisms to achieve controlled and efficient renal excretion to improve potential clinical translation.

