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Towards precision medicine using biochemically triggered cleavable conjugation.

Badri Parshad^1,2, Smriti Arora³, Balram Singh⁴

¹Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Communications Chemistry

|April 2, 2025

Summary

This summary is machine-generated.

Biochemically cleavable conjugations enable targeted drug release by responding to specific disease environments. This precision medicine approach minimizes side effects and enhances therapeutic efficacy in various applications.

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Area of Science:

Biomedical Engineering
Drug Delivery Systems
Materials Science

Background:

Personalized and precision medicines are advancing therapeutic strategies.
Biochemically triggered cleavable conjugation is vital for responding to loco-regional environments.
This approach enables targeted release of therapeutics, reducing off-target effects and improving treatment precision.

Purpose of the Study:

To provide a comprehensive review of biochemically cleavable conjugations in stimuli-responsive architectures.
To highlight the significance of these conjugations for personalized medicine.
To classify intrinsic physicochemical differences in pathological areas and their applications.

Main Methods:

Extensive literature review of biochemically cleavable conjugations.
Analysis of pathological microenvironments (pH, redox, hypoxia, ROS, enzyme levels).
Classification of stimuli-responsive systems for drug delivery, imaging, and theranostics.

Main Results:

Biochemical triggers in pathological sites (e.g., tumors, inflammation) can be leveraged for targeted drug release.
Cleavable conjugations offer precise control over therapeutic agent delivery.
Diverse applications including cancer therapy, senolytics, gene therapy, and regenerative medicine are enabled.

Conclusions:

Biochemically cleavable conjugations are crucial for developing intelligent, stimuli-responsive bio-engineered systems.
Understanding microenvironmental triggers is key to designing effective targeted therapies.
This review offers guidance for designing advanced functional cleavable conjugations for future personalized medicines.