Related Experiment Video

Updated: Aug 5, 2026

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
09:22

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

Human chaperone DNAJB6b suppresses tau fibril formation through co-aggregation

Andreas Carlsson1, Emil Axell2, Johan Wallerstein3

  • 1Biochemistry and Structural Biology, Lund University, Lund, Sweden. andreas.carlsson@chem.lu.se.

Communications Chemistry
|August 3, 2026
PubMed
Summary

DNAJB6b protein significantly inhibits tau aggregation, a key factor in Alzheimer's disease pathology. It achieves this by binding to tau aggregates and fibrils, reducing their growth and increasing tau solubility.

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