Related Experiment Video
Updated: Sep 21, 2025

07:56
Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
Published on: January 26, 2018
16.7K
Optimal uterotonic management
Michael Heesen1, Sharon Orbach-Zinger2
1Department of Anaesthesia, Kantonsspital Baden, Baden, Switzerland.
Best Practice & Research. Clinical Anaesthesiology
|June 6, 2022
Summary
Uterotonics manage postpartum hemorrhage. Oxytocin is first-line, but alternatives like carbetocin are vital when oxytocin fails or for patients with cardiovascular issues.
Area of Science:
- Obstetrics and Gynecology
- Pharmacology
Background:
- Postpartum hemorrhage (PPH) management relies on uterotonics.
- Oxytocin, the first-line agent, can cause receptor desensitization.
- Alternative uterotonics are needed when oxytocin is insufficient.
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