Mouse models in COVID-19 research: analyzing the adaptive immune response

Area of Science:

• Virology
• Immunology
• Infectious Diseases

Background:

• The COVID-19 pandemic, caused by SARS-CoV-2, necessitated rapid development of medical countermeasures.
• Understanding SARS-CoV-2 pathogenesis is crucial for creating effective therapeutics and vaccines.
• Animal models are essential for preclinical studies of infection, vaccination, and treatment.

Purpose of the Study:

• To provide an overview of animal models utilized in SARS-CoV-2 research.
• To highlight the significance and application of mouse models in SARS-CoV-2 studies.
• To discuss the analysis of SARS-CoV-2-specific T cell responses in infected and vaccinated mice.

Main Methods:

• Review of existing literature on animal models for SARS-CoV-2.
• Comparative analysis of different animal models based on their suitability for SARS-CoV-2 research.
• Focus on the use and advantages of mouse models in SARS-CoV-2 infection and vaccination studies.

Main Results:

• Various animal models have been employed in SARS-CoV-2 studies, exhibiting diverse clinical outcomes.
• Mouse models are well-established and widely used due to their laboratory adaptability.
• Specific mouse models have been developed for SARS-CoV-2 research, facilitating detailed investigations.

Conclusions:

• Animal models are indispensable tools for advancing our understanding of SARS-CoV-2 and developing interventions.
• Mouse models offer a versatile platform for studying SARS-CoV-2 infection, pathogenesis, and immune responses.
• Further research utilizing these models will aid in the development of vaccines and therapies against COVID-19.